MASTER TOPICS - OFFERED BY ISTEM STUDY COURSE

– iPS based in vitro modelling of Crigler-Najjar syndrome type 1
– Characterisation of MSCs and iPSCs derived from urine

Prof. Dr. James Adjaye
Inst. für Stammzellforschung und Regenerative Medizin
HHU Düsseldorf
James.Adjaye@med.uni-duesseldorf.de
Tel.: 0049(0)211-81-08192

– Reduction of ischemic and reperfusion damage in skeletal muscle

Prof. Dr. med. Björn Behr
Plastische Chirurgie Bergmannsheil
Bürkle-de-la-Camp-Platz 1
44789 Bochum
Bjorn.behr@rub.de
0234-302-359

– Stem cell studies and cell culture optimization using a 3D-Bioprinter
– Studying autophagy in epithelial-mesenchymal transitions in the chicken embryo
– Studying autophagy in developmental processes in murine iPS cells
– Morphological and molecular analysis of Math6 knockout mice
– Functional analysis of Math6 in the myogenic differentiation
of adult skeletal muscle stem cells using knockout mice
– Differential myogenic microRNA expression profiling in adult skeletal muscle stem cells of Math6 knockout mice

Prof. Dr. Beate Brand-Saberi
Anatomie und Molekulare Embryologie
Ruhr-Universität Bochum
MA 5/158
Beate.Brand-Saberi@rub.de
0234-32-24556

– Molecular analysis of genes co-regulated by Bcl11a/b transcription factors in murine neocortical development

Professor Dr. Stefan Britsch
Institute of Molecular and Cellular Anatomy
Ulm University
Albert-Einstein-Allee 11
89081 Ulm
stefan.britsch@uni-ulm.de
0731/500 23100

– Adhesion of circulating cancer stem cells to endothelial cells in vitro
– Selective inhibition of cancer stem cells by the combination of ionophors (salinomycin) and metformin
– Role of the acid sphingomyelinase/ ceramide pathway in post-ischemic neuroplasticity and angiogenesis

Prof. Dr. med. Irenäus Adamietz
Klinik für Strahlentherapie und Radio-Onkologie
Marien Hospital Herne – Universitätsklinikum
der Ruhr-Universität Bochum
Hölkeskampring 40,
44625 Herne
Fon: 02323 499-1531
Fax: 02323 499-3306
strahlentherapie@marienhospital-herne.de

Theses available around the general topics:
– Bioinformatics for Proteomics
– Analysis Methodology for Mass Spectrometry Data
– Biostatistics for Quantitative Proteomics / Peptidomics Data
– requirement: successful participation in lecture “Bioinformatics for
Proteomics I” (Veranstaltungsnummer 201911)

PD Dr. Eisenacher
Group Leader Algorithmic
Proteomics Medizinisches Proteom-Center
DEPARTMENT Medical Bioinformatics
Building ProDi E2.244 | Gesundheitscampus 4 |
D-44801 Bochum
Fon +49 (0)234 32-18108 | Fax +49 (0)234 32-14496
www.medizinisches-proteom-center.de

Hematopoietic Stem Cell Transplantation:

– Impact of the peptidome on T cell alloreactivity to polymorphic human leukocyte antigen (HLA) molecules
– Immunogenicity of antigen presenting cells after Crispr-Cas9 silencing of HLA class II
– Characterization of the human T cell receptor repertoire responding to HLA mismatches after
hematopoietic stem cell transplantation
– Effect of amino acid polymorphism in HLA-DP on the repertoire of presented peptides
– Role of HLA-DM for the immunogenicity of leukemia cells after hematopoietic stem cell transplantation
– Characterization of HLA loss leukemia immune escape after hematopoietic stem cell transplantation
by droplet digital PCR

Prof. Dr. med. Katharina Fleischhauer
University Hospital Essen
Institute for Experimental Cellular Therapy
Hufelandstraße 55
D-45122 Essen
Telefon +49 201 / 723-4582
katharina.fleischhauer@uk-essen.de

– Influence of conditionally induced Reelin-knockout on hippocampal stem cell
proliferation and differentiation

Prof. Eckart Förster
Institut für Neuroanatomie und
molekulare Hirnforschung
Ruhr-Universität Bochum
MA 6 Süd/161
Eckart.Foerster@rub.de
0234/3225002

Human Hematopoiesis:

– The impact of signaling pathways on early hematopoiesis and dendritic cell development

MSC-EVs/Exosomes:
– Establishment of novel reporter cell lines to dissect the activity of MSC-EVs
– Impact of different EV purification methods on the biologic activity of MSC-EVs
– Analysis of the heterogeneity of plasma derived extracellular vesicles
– Impact of small molecules on the EV secretion of mesenchymal stem cells
– Analysis of the lipid raft composition of different MSC-EV subpopulations

Prof. Dr. Bernd Giebel
University Hospital Essen
Institute for Transfusion Medicine
Hufelandstraße 55
45122 Essen
Tel. 0201/723-4204
Bernd.Giebel@uk-essen.de

Hematopoiesis:

– Development of hematopoietic stem- and progenitor cells from pluripotent stem cells, in vitro

PD. Dr. Hannes Klump
University Hospital Essen
Institute for Transfusion Medicine
Hufelandstraße 55
45122 Essen
Tel. 0201/723-4204
hannes.klump@uk-essen.de

– Secondary Resistance towards targeted therapies in colon and pancreatic cancer: The role of persister cells in the context of the stem cell-​like characteristics of persister cells

Prof. Dr. med. Stephan Hahn
Ruhr-Universität Bochum
Zentrum für Klinische Forschung (ZKF)
Labor für Molekulare Gastroenterologische Onkologi (MGO)
der Medizinischen Universitätsklinik Knappschaftsk.
Universitätsstraße 150
44780 Bochum
Tel +49 (0) 234 32 29282 Fax +49 (0) 234 32 14674
stephan.hahn@rub.de
www.rub.de/mgo

– Role of the acid sphingomyelinase/ ceramide pathway in post-ischemic neuroplasticity
and angiogenesis
– Effects of mescenchamal stem cell-derived exosomes on post-ischemic brain remodeling
and plasticity
– Effects of GABAA antagonists on post-ischemic brain remodeling and plasticity
– Molecular mechanisms of primary neuronal and neuronal stem cell differentiation under inflammatory
and ischemic conditions

Prof. Dr.med. Dirk M. Hermann
Chair of Vascular Neurology,
Dementia and Ageing Research/ NeuroScienceLab
University Hospital Essen
Hufelandstraße 55,
45122 Essen
dirk.hermann@uk-essen.de
0201/723-2180

– Development of the head trunk transition region

Prof. Dr. med. Ruijin Huang
Institute of Anatomy University of Bonn
Nussallee 10, 53115 Bonn
ruijin.huang@uni-bonn.de
Tel. 0228-73-5618

– The role of hCAP-18/LL-37 as a mediator between epidermal and mesenchymal stem cells
during wound healing and skin tissue regeneration

Dr. Frank Jacobsen
Arbeitsgruppe Experimentelle Plastische Chirurgie Klinik
für Plastische Chirurgie und Schwerbrandverletzte Handchirurgiezentrum

BG Universitätskliniken Bergmannsheil
Ruhr-Universität Bochum
Bürkle-de-la Camp Platz 1
D-44789 Bochum
frank.jacobsen@ruhr-uni-bochum.de
www.bergmannsheil.de

– “Development of Gut-on-a-chip model for disease modelling”

Dr. Dorota Kurek
Head of Research/Model Development Mimetas

– Analysis of neuronal proteins within in the human brain in the context of ageing
– Analysis of neuronal proteins within in the human brain in the context of neurodegenerative diseases
– Analysis of autoantibodies in human diseases
– Analysis of autoantibodies in healthy individuals – Proteome analyses of CSF and exosomes for the identification of biomarkers for spinal cord injury

Prof. Dr. Katrin Marcus
Ruhr-Universität Bochum
Zentrum für klinische Forschung (ZKF)
Raum 1.055
katrin.marcus@rub.de
0234/32-28444

– Extracellular vesicles as a potential diagnostic tool to measure cancer stem cell heterogeneity
in pediatric Rhabdoid Tumor patients.
– Profiling of extracellular vesicles from pediatric AML patients to track the evolution of rare leukemic
stem cells sub-clones in the hematopoietic compartment.
– Extracellular vesicles based liquid biopsy in solid tumor patients (either melanoma or the cancer of head and neck)
to track the clonal evolution and resistance of aggressive cancer stem cells.

Dr. Basant Kumar Thakur
Experimental Molecular Research Pediatric Clinic III
University Clinic of Essen
Hufelandstraße 55
D- 45147 Essen

Tel: +49 201/ 723-2502

– Cell-to-cell transmission of pathogenic proteins linked to neurodegenerative diseases in humans

Prof. Dr. Jörg Tatzelt
Institut für Biochemie und Pathobiochemie,
Abteilung Biochemie Neurodegenerativer Erkrankungen
Ruhr-Universität Bochum
MA 2/145
joerg.tatzelt@rub.de
0234/ 32-22429

– Effect of New Cathepsin K Inhibitors on the Osteogenic and Vascular Cell Differentiation

Prof. Dr. Edda Tobiasch
Hochschule Bonn-Rhein-Sieg
von-Liebig-Str. 20
53359 Rheinbach
edda.tobiasch@h-brs.de
02241/865576

– Biochemical characterization of a germeline-specific epitope on the surface of the mammalian mitochondrium

Prof. Dr. Christoph Viebahn
Zentrum Anatomie Uni. Göttingen
Kreuzbergring 36
D−37075 Göttingen
christoph.viebahn@medizin.uni-goettingen.de
+49 (0)551 397001

– Analysis of an in vitro model for neural differentiation
– Differentiation capacities for murine neural stem cells
– Influence of Cytochrome C on neural stem cell behavior

Prof. Dr. Stefan Wiese
AG Molecular Cell Biology
Ruhr-Universität Bochum, NDEF 05
stefan.wiese@ruhr-uni-bochum.de
0234/32-22041

– Modeling skeletal muscular dystrophies with patient-derived induced pluripotent stem cells

PD Dr. Holm Zähres
Anatomie und Molekulare Embryologie
Ruhr-Universität Bochum
MA 5/152
holm.zaehres@rub.de
0234/32-25714

– Developing an in vitro model for hypertrophy induction of human induced pluripotent
stem cell-derived cardiomyocytes (hiPSC-CMs)

Dr. Robert Zweigerdt
and Dr. Henning Kempf
Medizinische Hochschule Hannover (MHH),
Abteilung: Leibniz Research Laboratories
for Biotechnology and Artificial Organs (LEBAO)
Carl-Neuberg-Str.1, 30625 Hannover
zweigerdt.robert@mh-hannover.de
0511 / 532 8773

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