Ruhr University Bochum

Molecular and Developmental Stem Cell Biology



– iPSC based in vitro modelling of Crigler-Najjar syndrome type 1
– Characterisation of MSCs and iPSCs derived from urine

Prof. Dr. James Adjaye
Inst. für Stammzellforschung und Regenerative Medizin
HHU Düsseldorf
Tel.: 0049(0)211-81-08192

-Reduction of ischemic and reperfusion damage in skeletal muscle

Prof. Dr. Björn Behr
Plastische Chirurgie Bergmannsheil
Bürkle-de-la-Camp-Platz 1
44789 Bochum

-Stem cell studies and cell culture optimization using a 3D-Bioprinter
-Studying autophagy in epithelial-mesenchymal transitions in the chicken embryo
-Studying autophagy in developmental processes in murine iPS cells
-Morphological and molecular analysis of Math6 knockout mice
-Functional analysis of Math6 in the myogenic differentiation
of adult skeletal muscle stem cells using knockout mice
-Differential myogenic microRNA expression profiling in adult skeletal muscle stem cells of Math6 knockout mice

Prof. Dr. Beate Brand-Saberi
Anatomie und Molekulare Embryologie
Ruhr-Universität Bochum
MA 5/158

-Adhesion of circulating cancer stem cells to endothelial cells in vitro
-Selective inhibition of cancer stem cells by the combination of ionophors (salinomycin) and metformin
-Role of the acid sphingomyelinase/ ceramide pathway in post-ischemic neuroplasticity and angiogenesis

Prof. Dr. Irenäus Adamietz
Klinik für Strahlentherapie und Radio-Onkologie
Marien Hospital Herne – Universitätsklinikum
der Ruhr-Universität Bochum
Hölkeskampring 40,
44625 Herne
Fon: 02323 499-1531
Fax: 02323 499-3306

Theses available around the general topics:
–Bioinformatics for Proteomics
–Analysis Methodology for Mass Spectrometry Data
–Biostatistics for Quantitative Proteomics / Peptidomics Data
–requirement: successful participation in lecture “Bioinformatics for Proteomics I” (Veranstaltungsnummer 201911)

Prof. Dr. Eisenacher
Group Leader Algorithmic
Proteomics Medizinisches Proteom-Center
DEPARTMENT Medical Bioinformatics
Building ProDi E2.244 | Gesundheitscampus 4 D-44801 Bochum
Fon +49 (0)234 32-18108 | Fax +49 (0)234 32-14496

Hematopoietic Stem Cell Transplantation:
-Impact of the peptidome on T cell alloreactivity to polymorphic human leukocyte antigen (HLA) molecules
-Immunogenicity of antigen presenting cells after Crispr-Cas9 silencing of HLA class II
-Characterization of the human T cell receptor repertoire responding to HLA mismatches after
hematopoietic stem cell transplantation
-Effect of amino acid polymorphism in HLA-DP on the repertoire of presented peptides
-Role of HLA-DM for the immunogenicity of leukemia cells after hematopoietic stem cell transplantation
-Characterization of HLA loss leukemia immune escape after hematopoietic stem cell transplantation
by droplet digital PCR

Prof. Dr. Katharina Fleischhauer
University Hospital Essen
Institute for Experimental Cellular Therapy
Hufelandstraße 55
D-45122 Essen
Telefon +49 201 / 723-4582

-Influence of conditionally induced Reelin-knockout on hippocampal stem cell proliferation and differentiation

Prof. Dr. Eckart Förster
Institut für Neuroanatomie und
molekulare Hirnforschung
Ruhr-Universität Bochum
MA 6 Süd/161

Human Hematopoiesis:
-The impact of signaling pathways on early hematopoiesis and dendritic cell development
-Establishment of novel reporter cell lines to dissect the activity of MSC-EVs
-Impact of different EV purification methods on the biologic activity of MSC-EVs
-Analysis of the heterogeneity of plasma derived extracellular vesicles
-Impact of small molecules on the EV secretion of mesenchymal stem cells
-Analysis of the lipid raft composition of different MSC-EV subpopulations

Prof. Dr. Bernd Giebel
University Hospital Essen
Institute for Transfusion Medicine
Hufelandstraße 55
45122 Essen
Tel. 0201/723-4204

-Development of hematopoietic stem- and progenitor cells from pluripotent stem cells, in vitro

Prof. Dr. Hannes Klump
Uniklinik RWTH Aachen
Institut für Transfusionsmedizin und Zelltherapeutika
Pauwelsstr. 30
52074 Aachen
Tel. 0241/80-88715

-Secondary Resistance towards targeted therapies in colon and pancreatic cancer: The role of persister cells in the context of the stem cell-​like characteristics of persister cells

Prof. Dr. Stephan Hahn
Ruhr-Universität Bochum
Zentrum für Klinische Forschung (ZKF)
Labor für Molekulare Gastroenterologische Onkologi (MGO)
der Medizinischen Universitätsklinik Knappschaftsk.
Universitätsstraße 150
44780 Bochum
Tel +49 (0) 234 32 29282 Fax +49 (0) 234 32 14674

-Analysis of neuronal proteins within in the human brain in the context of ageing
-Analysis of neuronal proteins within in the human brain in the context of neurodegenerative diseases
-Analysis of autoantibodies in human diseases
-Analysis of autoantibodies in healthy individuals – Proteome analyses of CSF and exosomes for the identification of biomarkers for spinal cord injury

Prof. Dr. Katrin Marcus
Ruhr-Universität Bochum
Zentrum für klinische Forschung (ZKF)
Raum 1.055

-Extracellular vesicles as a potential diagnostic tool to measure cancer stem cell heterogeneity
in pediatric Rhabdoid Tumor patients.
-Profiling of extracellular vesicles from pediatric AML patients to track the evolution of rare leukemic
stem cells sub-clones in the hematopoietic compartment.
-Extracellular vesicles based liquid biopsy in solid tumor patients (either melanoma or the cancer of head and neck)
to track the clonal evolution and resistance of aggressive cancer stem cells.

Dr. Basant Kumar Thakur
Experimental Molecular Research Pediatric Clinic III
University Clinic of Essen
Hufelandstraße 55
D- 45147 Essen
Tel: +49 201/ 723-2502

-Cell-to-cell transmission of pathogenic proteins linked to neurodegenerative diseases in humans

Prof. Dr. Jörg Tatzelt
Institut für Biochemie und Pathobiochemie,
Abteilung Biochemie Neurodegenerativer Erkrankungen
Ruhr-Universität Bochum
MA 2/145
0234/ 32-22429

-Analysis of an in vitro model for neural differentiation
-Differentiation capacities for murine neural stem cells
-Influence of Cytochrome C on neural stem cell behavior

Prof. Dr. Stefan Wiese
AG Molecular Cell Biology
Ruhr-Universität Bochum, NDEF 05

-Modeling skeletal muscular dystrophies with patient-derived induced pluripotent stem cells

-Direct reprogramming into neural stem / progenitor cells by defined transcription factors

PD Dr. Holm Zähres
Anatomie und Molekulare Embryologie
Ruhr-Universität Bochum
MA 5/152

-Developing an in vitro model for hypertrophy induction of human induced pluripotent
stem cell-derived cardiomyocytes (hiPSC-CMs)

Dr. Robert Zweigerdt
and Dr. Henning Kempf
Medizinische Hochschule Hannover (MHH),
Abteilung: Leibniz Research Laboratories
for Biotechnology and Artificial Organs (LEBAO)
Carl-Neuberg-Str.1, 30625 Hannover
0511 / 532 8773

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